Good News, HRT and Breast Cancer Decrease, But Hot Flashes Increase

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herbs for hot flashes and menopauseA dramatic decrease in use of hormone replacement therapy (HRT) during the past two years has also coincided with lower breast cancer incidence  according to a new study published in the Journal of the National Cancer Institute.  HRT was the recommended treatment for decades for menopause symptoms such as hot flashes, night sweats, brain fog and vaginal dryness to name a few. 

However, since 2002 when the Womens Health Initiative clinical trial announced an increase risk in breast cancer, stroke and heart attacks due to HRT,  doctors have limited their prescription writing of HRT.  It is fantastic to see a study showing breast cancer diagnosis dropping in the past two years, but many women have such debilitating menopause symptoms they still need something to help them cope.  It's unfortunate more women do not understand the benefits of herbal remedies for menopause, which can provide the comfort they desperatly seek. 

If you don't sleep well, soak through pajamas at night, hot flash during the day and often feel dazed and confused you could add a few Chinese herbs to your diet, by way of a tea.  You will have a decline of symptoms within a few weeks, within one month you will feel significant,  real relief.  But many women want a quick acting pill and that is not how herbal medicine works.  Our bodies  normally slowly enter the peri-menopause stage and then the complete end to menstruation.  Coping with the symptoms that arise from hormonal changes is not easy and it can take a little time to readjust the thermostat of the body.  Our herbal remedy for menopause does work. Our herbs have been written about and used continuously for over 2000 years.  More information about our Menopause Relief Herb Pac coming soon.

As always, thanks for reading our blog.

Study information can be found at:  J Natl Cancer Inst. Published online September 23, 2010.

http://www.medscape.com/viewarticle/729378?sssdmh=dm1.639367&src=nldne&uac=139834FJ

Jujube, What Makes It Such a Great Sleep Aid?

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What is this funny little fruit, known as jujube, and why is it known for promoting a deeper, more restful sleep?  In Chinese herbal medicine it is the seed of the fruit or spiny zizyphus.  Laboratory studies of zizyphus extract have confirmed the sedative effects.  In fact,  the latest research from France concluded the seeds of the fruit are rich in fatty acids and a host of other beneficial compounds which can benefit those who are looking for a natural sleep aid.

Jujube seeds are about the same size as a typical apple seed.  The seeds have been used in Traditional Chinese Medicine and in other ancient cultures for  hundreds of years.  The seeds are most commonly used for their sedative effects especially common as a sleep aid.    Yet, unlike so many other sedative plants or man made drugs, zizphus is extremely safe.     Drinking zizphus tea has been reported to have no toxicity even in huge doses such as 50 grams per kilogram of body weight, even for 30 consecutive days.

Modern pharmacology evaluation of zizyphus seed oil and zizyphus extract suggest that with prolonged feeding (to mice)  they can reduce serum triglycerides and cholesterol (mainly LDL), and reduce fatty degeneration of the liver. These same properties have also been attributed to the triterpenes of ganoderma and ginseng.  Connect here to articles on ginseng and ganoderma.

Jujube has increasingly become popular as a source of over-the-counter natural sleep aid.  In this just released study, different extracts of the Zizyphus exerted antioxidant activity. Hence, it is possible that the antioxidant activity of Zizyphus might be due to the presence of different vitamins and fatty acids.   The study also showed that Zizyphus decoction (cooked in water) exerted an immmuno-supressive activity.  Jujube is one of the main ingredients in our natural herbal sleep tea. For more information on our iSleep Herb Pac sleep aid click  here.

References:

Wu Shuyun, et al., Effects of zizyphus seed oil and zizyphus extract on decrease of serum lipoprotein and inhibition of platelet aggregation, China Journal of Chinese Materia Medica 1991.

The study quoted can be found at:  http://www.biomedcentral.com/content/pdf/1472-6882-10-54.pdf
Zizyphus lotus L. (Desf.) modulates antioxidant activity and human T-cell proliferation
Authors:  Chahid Benammar1§,2, Aziz Hichami2, Akadiri Yessoufou2, Anne-Marie Simonin2, Meriem
Belarbi1, Hocine Allali 3, and Naim A Khan2

Sleep Tips From The Mayo Clinic, Is Sleeping Now a Luxury?

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herbs for sleep Is Sleep a luxury?  As our world has become more modern, more convenient and more well, fast paced sleeping seems to be, more of a luxury than a necessity.  We can take pills to quickly put us to sleep and all kinds of drinks and foods to keep us awake.  We can regulate our bodies for 20 hour work days and 4 hours of rest,  or any combination thereof.   With hundreds of TV stations on 24 hours, movies on demand, internet, anytime, anywhere, there just seems like so many better things to do than sleep.  Even little kids know that it's usually much more fun to stay up late, than to go to bed.

Yes,  but our genetics tell us we need 8-9 hours of sleep every night. Sorry, overriding genetics on this issue will only deteriorate your health.  Here are the  highlights from an eight page report about sleeping well from the Mayo Clinic.  

  • Sleep isn’t a luxury, it is a necessity.
  • Restful sleep is just as important to health as adequate nutrition and exercise.
  • Sleep is necessary to think clearly.
  • Studies have shown that being well rested improves the body’s response to infection.
  • Evidence suggests that brains are hard at work during sleep, possibly forming the pathways necessary for learning, making new memories and insights, and coming up with creative solutions to problems.
  • Inadequate sleep is linked to depression and irritability as well as diabetes, weight problems and cravings for high-calorie, high-carbohydrate foods.
  • Sleep problems often can be treated, sleep aids can be both behavioral and medications.
  • In fact, sleep problems often can be traced to treatable health issues. Examples include poor pain control, frequent nighttime urination, or illnesses that cause coughing or shortness of breath.
  • Insomnia and depression often go hand in hand: Many people develop insomnia prior to being depressed. Studies show that unresolved insomnia increases the risk of depression. It’s not clear if one causes the other, but each can worsen if untreated.
  • Antidepressants may have stimulating properties and make insomnia worse. Prescription sleep aids are designed for short term use.

We believe in natural sleep aids here at Pac Herbs.  Our iSleep Herb Pac will help you rest and feel rejuvenated the next day. Get the sleep your body needs to stay healthy, because sleeping is not just a luxury but a necessity for wellness.  Checkout our all natural iSleep Herb Pac, an herbal formula used in Asian cultures for thousands of years.





Chemo Side Effects Reduced With Chinese Herbs, Says Yale

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Chemo patients helped with Chinese herbsThis remarkable research conducted at Yale University is incredible news for Americans.  Asian societies, on the other hand, have used these Chinese herbs for generations and understand that boiling peony root, with licorice root, red dates and skullcap root can help the gastro-intestinal tract especially when one is suffering from diarrhea.

The recently announced research proved a drug made from four traditional Chinese herbs, dubbed PHY906, countered the side effects of chemo in rats.  The researchers decided to give the mice, who were on a chemotherapy drug which has side effects of nausea, vomiting and diarrhea, this blend of natural herbs.   Not only did the four Chinese herbs improve the mices symptoms of diarrhea but it simultaneously cut the cancerous tumors growth.

 “This combination of chemotherapy and herbs represents a marriage of Western and Eastern approaches,” said lead researcher Dr. Yung-Chi Cheng.

A study such as this and so many others, are slowly beginning to open up American minds to the incredible health benefits of Chinese herbs. I found it interesting to listen to the interview with Dr. Cheng. He states that the four herbs must be used in combination and cooked together.  Used individually, they did not perform the same function. He says, “deletion of any of those herbs, you have a different impact on three biological endpoints.”  This is exactly what Chinese medicine textbooks have told us for years. It is the combination of herbs cooked together that create the synergy and provide the valuable healing medicinal action.

The use of complementary and alternative medicine (CAM) has become a core component in  treating cancer patients. Diarrhea is one of the major side effects of the cancer drug irinotecan.  According to  Dr. Yung-Chi Cheng this herbal remedy is based on the formula which was first established 1,800 years ago and is also known as Huang Qin Tang. It was historically used and still is used today for treatment of diarrhea and GI disorder[s].  The popularity of natural herbal medicine has been expanding each year in America as more studies like this are published.

Insomnia Thoughts, Chinese Herbs Will Change Your Mind

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Natural sleep aids like Chinese herbs work bestTip of the day:  The best treatment for insomnia according to researchers is to change your thought patterns.   Once you change your thoughts your behavior will follow. You see, what you think is what you get.  So it makes sense that insomnia really is, all in the mind. 

 Hint:  If you need a kick start to change your mind set without hitting the heavy prescription sleep aids, try our iSleep Herb Pac.  It contains nine herbs and is based on an ancient Chinese herbal formula called Suan Zao Ren Tang.  Famous minds have used Chinese herbs to help them calm their busy brains and induce a restful night of sleep for centuries. Nothing new under the sun here. Just natural substances found in plants, working together to help reduce stress and calm your head.  It will work for you too, without addiction or side-effects.    

By Jan Yager, Ph.D.
ConsumerAffairs.com

You’ve heard that expression, “I’ll sleep when I’m dead.” Well, it turns out that getting enough sleep, and other kinds of rest, just might postpone when your death occurs as well as increase the effectiveness and joyfulness of your life.

Consider this: the Nurses’ Health Study conducted by Harvard University found that getting too little sleep is linked to a greater risk of getting breast cancer, colon cancer, diabetes, and heart disease.

Furthermore, sleep deprivation causes drowsy driving which can lead to accident fatalities. As reported by The National Sleep Foundation at their website devoted to drowsy driving, the National Highway Traffic Safety Administration estimates that 1,500 deaths and 71,000 injuries are caused annually because of falling asleep at the wheel.

In another study, a review of information about 28,000 children and 15,000 adults found that too little sleep doubled the chances of being obese. Obesity has, in turn, been linked to a variety of life-threatening illnesses including sleep apnea, a condition in which we stop breathing during sleep. As pointed out in “Sleep Apnea Tied to Increased Risk of Stroke,” especially for men over the age of 40, having sleep apnea more than doubles their potential for a stoke.

Preventing an early death or decreasing the likelihood you will become obese aren’t the only reasons we need to get enough sleep and rest. We also need it so we can be alert at work, making it less likely that we’ll make mistakes, have accidents, or fall asleep during meetings, which could embarrass you or, worse, get you fired. Also, too little sleep can increase someone’s tendency to fly off the handle or to be overly emotional, reduce memory retention and increase depression. Simply put, too little sleep reduces the overall quality of our lives.

Natural Sleep Aid Tip for Children, Try Lavender

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From time to time I get calls asking if children can take iSleep Herb Pac.  While the herbs in the Pac Herbs product iSleep, are completely safe for children (adjusted to child's weight) on principal alone  I  do not recommend sleep aids for children.  The reason for this, and I am referring to approximate age of 13 and under, is generally speaking children our very healthy and should not have problems sleeping. 

Although it is not uncommon for teens to have sleep disorders usually due to stress, children younger than 10 normally will only have an occasional bad dream that wakes them and falling asleep is completely related to the amount of exercise they have done on any given day.   If your adolescent is having sleep problems, you must figure out the source of the stress that is keeping him or her from a good nights sleep.  Providing a sleep aid pill will only exasperate the problem as they mature.

So what do you do when you are frazzled and tired of your rambunctious eight year old's bedtime getting later and later as a result of long summer days and the lack of a school routine?  Here's a suggestion for young children that is a completely natural sleep aid.

Use lavender essential oil, as little as two drops in a warm bath will relax those little wide eyed monsters and settle their spirits.  If they are not taking a bath the same two drops on their pillow will have a similar effect.    Another possibility,  take one drop of lavender essential oil and rub it in at a spot near the back of each ear lobe, (start at the back of the ear lobe and add two finger widths toward the back of head.) Rub a drop of lavender essential oil in the area to relax.  This spot is used in Chinese medicine and acupuncture to calm the CNS. It's name Anmian,  translated means peaceful sleep.

Lavender is a gentle, safe and effective sleep aid for children (and adults) with no habit forming tendencies.  Except of course, they may become so accustomed to the scent they will not want to fall asleep without it.   Don't worry, it is not terribly expensive.  I am always grateful for a good nights sleep and I been known to carry a small bottle of lavender oil with me when traveling. I love everything about lavender, the name, the color growing in my yard, and especially the smell.  It has a wonderfully calming scent with a gentle action of  soothing nerves, perfect for both children and pregnant women as a natural sleep remedy.

 

Pac Herbs reserves all rights. Reproduction in whole or in part without permission is prohibited.This information is not intended to treat, diagnose, cure, or prevent any disease. All material in this article is provided for educational purposes only. Always seek the advice of your physician or other qualified health care provider with any questions you have regarding a medical condition, and before undertaking any diet, exercise, or other health program.

Tiger Woods May Want to Check Out a Non-Prescription Sleep Aid

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I not really much for celebrity gossip but tabloids are reporting Tiger Woods texted his friend Rachel saying “I feel like taking pills is my only alternative” for sleep.  No doubt Tiger has been on the high stress life style for many years.  Fame and fortune do have a price and like millions of people, it’s easy to feel the only way to get a good nights sleep is with the help of a prescription drug.

Would somebody please pass him an  iSleep Herb Pack before he lands in rehab, or pass on an address and I will be happy to send him some.  Poor guy, somebody tell him Chinese herbs have been used for centuries to calm the mind and provide a peaceful, non-addictive way to fall asleep. I  actually feel terrible for anyone who must rely on prescription sleep aids.  It’s a terrible cycle to get into and one that is even harder to break and here is why Tiger should be shining this year.

Fast Facts About Tigers from Jennifer Dubowski, L.Ac.

Are you a Tiger?

You are if you were born in: 1902, 1914, 1926, 1938, 1950, 1962, 1974, 1986, or 1998.

The Tiger symbolizes character traits such as bravery, competitiveness and unpredictability. This courageous and fiery fighter was admired by the ancient Chinese as the zodiac sign that kept away the three main tragedies of a household: fire; thieves; and ghosts. The Tiger has other strong qualities and is: a natural leader; generous, intelligent and always alert. Tigers love to be the center of attention and are very charming, although they have a slight tendency to be selfish. Just as their jungle counterparts rely on instinct, so do individuals born in the Chinese Year of the Tiger. The best jobs for Tigers are those that will lead them towards positions of leadership. Tigers make interesting partners – they are creative, passionate and will never bore their mates. They’re expressive, polite and trustworthy, but watch out. Partners need to have a high energy level and a sense of adventure to keep up with a Tiger.

Celebrities born under the sign of the Tiger include: Emily Bronte, Leonardo DiCaprio, Karl Marx, Marilyn Monroe, Marco Polo and Queen Elizabeth II.

Those individuals born in the Year of the Tiger are compatible with the Chinese astrological signs of Horse, Dog, and Dragons. They are incompatible with Goat and Ox.

Colors are Green, Purple

 

 

No Chinese Herbs, Just Gratitude

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I wanted to post something different, something completely off  the topic of Chinese herbal medicine.  Sometimes life is just short and passing us by and without a little gratitude we forget how good life can really be. And not every blog needs to always talk about Chinese herbs, everyday.

So here’s a thought… If you have food in your fridge, clothes on your back, a roof over your head and a place to sleep, you are richer than 75% of the world.  To feel even more grateful read the rest below.


Thanks and credit to Jason Mraz.

Sleeping Through The Night, Naturally

Posted by Cathy on

Best natural herbal sleep aid is Ziziphi or Suan Zao Ren Having a good night of sleep can make all the difference in having a good day ahead.  The video below gives some good ideas about Western herbs for sleep and some foods that may help calm you down in the evening. But unfortunately, the dietitian in this segment of Fox News has obviously not heard of Chinese herbs that are commonly used as sleep aids. Drinking  Ziziphi or Suan Zao Ren tea, otherwise known as  spiny jujube seed, can give you as much if not more relaxation as chamomile tea or valerian tea.  Americans are not as familiar with Chinese herbs because they are not yet as pervasive on the store shelves, but they are coming. (Ours are already here)  As the world gets smaller, Americans are learnimg more about convention herbal medicines from far away places such as China. 

In Traditional Chinese Medicine, ziziphi seed is widely used with other herbs for the treatment of insomnia.  I was in a health food store the other day talking to people about  iSleep Herb Pac and it was inspiring to hear talk so many people who want to end their addiction to prescription sleep aids.   Natural alternatives to sleepless nights do exist.   Herbs used in Asia for generations like spiny jujube/ziziphi are the new natural drug of choice.

There are many studies which have examined the effective components of this herb. They have all come to similar conclusions, the sedative and hypnotic effects of jujube seeds come from three important compounds, flavonoids, saponins, and polysaccharides all found inside. The combination and concentration of these chemicals and  is truly remarkable in each little seed.  Together these active chemicals prolong sleep time, provide more REM sleep and decrease sleep latency, or the time it takes to fall asleep.  Some studies point more to the saponins, also found in many foods (ie, alfalfa, fenugreek, oats and potatoes) which help you feel that sedative effect.  Asian cultures have known these effects for generations, they never needed a study to know that suan zao ren helps you sleep.  They know from experience, past down from generation to generation. They also know Chinese herbs are more effective when combined together with other herbs. But we're still learning.

Pub Med study on Semen Ziziphi spinosae/ Suan Zao Ren

Sleep More For Natural Weight Loss

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Natural Sleep aids help with Weight LossScientists have known for years that sleeping more can actually help you lose weight.  There are many studies to support this conclusion.  One such study published in  2005 which included 8000 adults over several years found that less sleep corresponded to greater risks of weight gain.  Is the answer to the American obesity problem in the bedroom?  It's true that eating and sleeping cannot really occur at the same time.

The American Journal of Clinical Nutrition studied a small group of men and women and measured their food intake over 48 hours periods.  One period of time included 8 hours of sleep and another in which the participants slept only 4 hours.   After the night of less sleep the men consumed more than 500 extra calories or approximately 22% more.   

The University of Chicago did a similar study last year and and similar findings in both men and women.  The less sleep the more calories eaten, particularly carbohydrates.   Makes sense to me, when I haven't gotten a good nights sleep I tend to make up for my lack of energy with food.   Some studies blame the gain on hormones.  They argue decreased sleep creates a spike in ghrelin, a hormone that stimulates appetite and an increase in leptin, which signals satiety.  But there seems to be no consensus yet.  Regardless, sleep aids such as Chinese herbs can help you stay asleep and give you the rest you need,  without side-effects or additional calories.  Prescription sleep aids in comparison with placebo pills only provided 11.4 minutes of additional rest but then, that is a subject for another bog. 

What do you think?  Does a night of better sleep equal less food intake the next day?

 

http://www.ncbi.nlm.nih.gov/pubmed/18719052  Eur J Endocrinol. 2008 Dec;159 Suppl 1:S59-66. Epub 2008 Aug 21. Sleep and the epidemic of obesity in children and adults.

Bitter Melon to Ward Off Breast Cancer Cells

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What vegetable is green, oblong, with the skin of a toad and the name of a fruit? The answer is bitter melon,  a tropical native popular in  South Asia and India.  Most Westerners would cringe at the taste. But it’s time it start showing up in American diets now that a new study from The Journal of Cancer Research, (March 1 issue) indicates  bitter  melon may also ward off breast cancer.

Bitter melon has been used in Traditional Chinese herbal Medicine for ages.  This study, published by the American Association of Cancer Research and conducted in St. Louis MO,  showed this Chinese herb has an ability to slow the growth and in some cases kill breast cancer cells.

Breast cancer is the most common cancer of women in the U.S.  It’s time prevention, not just research for a cure, be emphasized, including dietary changes to effectively stop the spread of this deadly cancer.

Chinese herbal medicine commonly uses bitter melon for the treatment of diabetes.  It is naturally high in Vitamin C, calcium, has twice the potassium of  bananas, twice the beta carotene of  broccoli and is fiber and B vitamin rich. Now we should add breast cancer prevention to the list of what this incredible, edible, Chinese herb can do.

This Chinese herbs preventative properties need to be publicized.  Prevention is not only more cost effective, it is the solution to all our health challenges as we age.   Staying healthy and happy is a health goal we all share.  Find some bitter melon today and eat your way to good health.

Link to the study here

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Another  study  just published in the Journal of the National Cancer Institute reported having a double mastectomy, or removing an otherwise healthy breast to prevent breast cancer from occurring in  healthy tissue had no added benefit.  This was a population study conducted by MD Anderson in Houston TX.  Surgery as a prevention against breast cancer had no measurable benefit.

Connect to this study here

Study Shows Chinese Herbs Help Sleeplessness

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iSleepherbpac.comAsian countries commonly treat sleeplessness with Chinese herbs more affordably and without the side-effects associated with prescriptions. A study done in Taiwan showed patients complaining of  insomnia were successfully treated with Chinese herbs.  

 

This study included 16,134 participants who received a total of 29,801 Chinese Herbal Medicine prescriptions. This large-scale study which used data assembled by the National Health Insurance of Taiwan, evaluated the frequency and patterns of Chinese herbs in treating insomnia. 

What’s unusual about this study is not just the sheer numbers of participants but the amount of data collected. Read the full study here.

The reason the study has such a large group of participants is simply that Taiwan has instituted a unique computerized data entry system as part of its health care system.  Patients can choose to visit either a Western hospital or a Traditional Chinese Medicine hospital. All data from patient visits are recorded in a national computer database. Because data is readily available in electronic form, large scale analysis is easy. Data in this study covers the course of one year.  The numbers reflect the patients who, according to diagnostic codes for insomnia, were treated with Traditional Chinese Herbal Medicine in 2002.

Included in this data are the following:

  • How many patients complained of insomnia, demographics on age, sex, etc?
  • How many patients were prescribed various Chinese herb formula combinations in packets? (herbal packets are the preferred delivery method of Chinese herbs in Taiwan hospitals and clinics.)
  • How many patients were prescribed single Chinese herbs in packets?
  • Which Chinese herb formula was the most prescribed?
  • Which individual herbs were often added to the prescribed Chinese herbal medicine formula?

Conclusion:

The data concluded the most common individual Chinese herbs prescribed for insomniawere Polygonum multiflorum used 23.8% of the time, followed by Ziziphus spinosa (18.3%) and Poria cocos (13.3%). Suan Zao Ren Tan was the most commonly prescribed formula.  These are the same Chinese herbal ingredients found in iSleep Herb Pack.

_____________________________________________________________________________________________ PUBLISHED IN:   EVIDENCE-BASED COMPLEMENTARY & ALTERNATIVE MEDICINE CAM Advance Access published online on April 1, 2009 eCAM, doi:10.1093/ecam/nep018 © 2009 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Prescriptions of Chinese Herbal Medicines for Insomnia in Taiwan during 2002 Fang-Pey Chen1,2, Maw-Shiou Jong1,2, Yu-Chun Chen2,3, Yen-Ying Kung1,2, Tzeng-Ji Chen2,3, Fun-Jou Chen4 and Shinn-Jang Hwang2,3 1Center for Traditional Medicine, Taipei Veterans General Hospital, 2National Yang-Ming University School of Medicine, Taipei, 3Department of Family Medicine, Taipei Veterans General Hospital and 4Graduate Institute of Integration Chinese and Western Medicine, Chinese Medical University, Taichung, Taiwan

Chinese herbal medicine (CHM) has been commonly used for treating insomnia in Asian countries for centuries. The aim of this study was to conduct a large-scale pharmaco-epidemiologic study and evaluate the frequency and patterns of CHM use in treating insomnia.

We obtained the traditional Chinese medicine (TCM) outpatient claims from the National Health Insurance in Taiwan for the year 2002. Patients with insomnia were identified from the diagnostic code of the International Classification of Disease among claimed visiting files.

Corresponding prescription files were analyzed, and an association rule was applied to evaluate the co-prescription of CHM. Results showed that there were 16 134 subjects who visited TCM clinics for insomnia in Taiwan during 2002 and received a total of 29 801 CHM prescriptions. Subjects between 40 and 49 years of age comprised the largest number of those treated (25.3%). In addition, female subjects used CHMs for insomnia more frequently than male subjects (female: male = 1.94:1). There was an average of 4.8 items prescribed in the form of either an individual Chinese herb or formula in a single CHM prescription for insomnia. Shou-wu-Teng (Polygonum multiflorum) was the most commonly prescribed single Chinese herb, while Suan-Zao-ren-tang was the most commonly prescribed Chinese herbal formula.

According to the association rule, the most commonly prescribed CHM drug combination was Suan-zao-ren-tang plus Long-dan-xie-gan-tang, while the most commonly prescribed triple-drug combination was Suan-Zao-ren-tang, Albizia julibrissin, and P. multiflorum.

For reprints and all correspondence: Prof. Shinn-Jang Hwang, Department of Family Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan, ROC. Tel: +886-2-287-57460; Fax: +886-2-287-37901; E-mail: sjhwang@vghtpe.gov.tw

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National Institute of Health – PubMed study abstract on Suan Zao Ren Tang

J Biomed Sci. 2007 Mar;14(2):285-97. Epub 2006 Dec 7.

Gamma-aminobutyric acid (GABA) receptor mediates suanzaorentang, a traditional Chinese herb remedy, induced sleep alteration.

Yi PL, Tsai CH, Chen YC, Chang FC.

Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan.

Abstract

The sedative-hypnotic medications, including benzodiazepines and non-benzodiazepines, are the most common treatments for insomnia. However, concerns regarding patterns of inappropriate use, dependence and adverse effects have led to caution in prescribing those sedative-hypnotic medications. On the other hand, a traditional Chinese herb remedy, suanzaorentang, has been efficiently and widely used in clinic for insomnia relief without severe side effects in Asia. Although suanzaorentang has been reported to improve sleep disruption in insomniac patients, its mechanism is still unclear. The present study was designed to elucidate the effects of oral administration of suanzaorentang on physiological sleep-wake architectures and its underlying mechanism in rats. We found that oral administration of suanzaorentang at the beginning of the dark onset dose-dependently increased non-rapid eye movement sleep (NREMS) during the dark period, but had no significant effect on rapid eye movement sleep (REMS). Our results also indicated that intracerebroventricular (ICV) administration of gamma-aminobutyric acid (GABA) receptor type A antagonist, bicuculline, significantly blocked suanzaorentang-induced enhancement in NREMS during the dark period, but GABA(B) receptor antagonist, 2-hydroxysaclofen had no effect. These results implicated that this traditional Chinese herb remedy, suanzaorentang increases spontaneous sleep activity and its effects may be mediated through the GABA(A) receptors, but not GABA(B) receptors.