Celestrol is a naturally occurring chemical in plants like the Thunder God Vine. It has been researched extensively as an anti-obesity drug, because of it’s action in helping with leptin resistance. However, the molecular mechanism for this activity is unknown. This plant is one of the hundreds commonly used in Traditional Chinese Medicine. Celestrol is NOT the magic bullet for weight loss but one study done on rats. Leptin is the hormone that stimulates appetite. Celestrol may help reduce appetite safely. However, when Thunder God Vine is used in Traditional Chinese Medicine, TCM, it is always used in a combination of herbs, or formula. This naturally occurring substance known as celestrol is only one of many chemicals in the Thunder God Vine. The supplements now on the market that have concentrated celestrol may not be a safe and effective way to take this chemical. It has no historical use and would never be used alone in one of the oldest herbal medicine traditions.
Diabetes Journal August 2018