Traditional Chinese Herb For Prostate

Herbs for prostate cancerA new drug is being resesarched for its early success in the treatment of prostate cancer. This is noteworth here because the drug is derived from a Chinese herb.


Like so many of our modern pharmaceuticals, the chemicals for this drug comes from a plnat which has been part of  Traditional Chinese Medicine Materica Medica for several centuries, and for prostate cancer treatment it looks very promising. 


The drug called Celastrol, is extracted from the "Thunder God Vine" Tripterygium wilfordii which has potent anti-inflammatory and antioxidant properties.  There are many Chinese herbs with anti-inflammatory effects and you can read about some of them in other blogs listed below. 


The drug seems to suppress the activity of a protein called p23. New research shows that p23 independently plays a key role in the way prostate tumors are fueled by the male hormone testosterone.


"Excitingly, drugs that block p23 such as celastrol.. have shown early promise in treating several diseases, such as arthritis and asthma, meaning this research is already a step closer to the clinic," said study leader Dr Charlotte Bevan, from Imperial College London, whose findings are reported in the journal Molecular Endocrinology.


"The next stage will be to test the effects of such drugs on prostate cancer cells in the lab."


Dr Julie Sharp, senior science information manager at the charity, said: "These results provide an alternative route by which scientists could potentially target prostate cancer. What's more, p23 has a much more defined role in the cell than HSP90, meaning that drugs that target it could potentially have fewer side effects than HSP90 inhibitors. We hope these findings will lead to better treatment options for men with prostate cancer."



Slowing Prostate Cancer with Chinese Herb Ling Zhi

I try to bring important medical research articles to this forum to keep readers educated, through scientific studies, on Chinese Herbs that exhibit extraordinary medical results.  This research was conducted in 2007 and although not as recent as some other studies I’ve mentioned,  it’s relevancy is certain worthy of reporting here. 

Researchers at the University of Haifa in Northern Israel, found molecules in the Ganoderma lucidum mushroom, (a popular Chinese herb) commonly known as the reishi or lingzhi in Chinese Medicine which help suppress some mechanisms involved in the progression of prostate cancer. Ling Zhi  seems to be able to slow the progress of disease.  The compounds identified in ling zhi were found help suppress some of the mechanisms involved in the progression of prostate cancer. They disrupt the activity of androgen receptors and impede the proliferation of cancerous cells.

Prostate cancer is one of the most common cancers among men over fifty. The normal development and maintenance of the prostate is dependent on androgen acting through the androgen receptor (AR).  Mutation of AR  may contribute to  prosate cancer and remains important in the development and progression of prostate cancer. Current medications used to treat prostate cancer works to reduce the production of androgens or to interfere with their function via the androgen receptor.

Prostate cancer progression is also associated with increased growth factors  and an altered response to growth factors by prostate cancer cells. It is thought this Chinese herb Ling Zhi helps modulate the signal pathways and may delay prostate cancer progression. This research started with 201 organic extracts from 68 types of fungi prepared with solvents such as ether, ethyl acetate and ethanol. They used these solvents to select molecules small enough to act from within the cells. From the 201 extracts, 11 successfully deter androgen receptor activity by more than 40%. Further testing showed that 169 extracts can inhibit growth of cancer cell. In this study, 14 extracts were found to be active in inhibiting prostate cancer cells.

From these active fungi extracts, the Chinese herb, Ganoderma Lucidum were tested as the most effective in inhibiting androgen receptor and controlling vital development of cancerous cells. "The results of this research are particularly interesting from a commercial aspect. Potential possibilities exist to establish research and development of bioactive components from Ganoderma Lucidum that could yield an anti-prostate cancer drug," remarked Dr. Zaidman.

This article is designed to provided the reader with clinical research results and the potential benefits and or risks associated with CAM (Complementary and Alternative Medicines). The author advocates neither for or against any particular therapy and recommends individuals speak with licensed medicial practitioners before using any Chinese herbal supplements or other health supplements.